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FIGURE 1 Over the past three decades, drug development based on the concept of “single-target blockade”—such as anti-endotoxin antibodies, specific TNF-α antagonists, or single anticoagulant agents—has repeatedly failed in clinical trials ( In the search for multi-target modulators, natural products—particularly bioactive small molecules derived from traditional medicine—have re-emerged as a research focus in critical care medicine due to their unique evolutionary advantages and chemical properties (Newman and Cragg, 2020)

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An unusual association of three autoimmune disorders: celiac disease, systemic lupus erythematosus and Hashimoto’s thyroiditis